The College of Sciences congratulates six of its graduate scholars who have won Herbert P. Haley Fellowships for the 2023-24 school year.

The new Haley Fellows are:

• Jessica Deutsch, School of Chemistry and Biochemistry
• Quynh Nguyen, School of Chemistry and Biochemistry
• Eliza Gazda, School of Physics
• Sydney Popsuj, School of Biological Sciences
• Jose Luis Ramirez-Colón, School of Earth and Atmospheric Sciences
• Sidney Scott-Sharoni, School of Psychology

Haley scholars receive a one-time merit award of up to $4,000 thanks to the generosity of the late Marion Peacock Haley. Haley’s estate established the creation of merit-based graduate fellowships at Georgia Tech in honor of her late husband, Herbert P. Haley (ME 1933). It is an award which may be held in conjunction with other funding, assistantships, or fellowships, if applicable. 

Meet the Haley Fellows

Jessica Deutsch

Jessica Deutsch is a fifth-year Ph.D. student studying analytical chemistry. “One of the most intriguing aspects of analytical chemistry is that the field focuses on studying invisible things in order to make sense of the visible,” Deuthsch says. “I am researching a deadly coral disease that affects Florida and Caribbean reefs. I aim to provide insight into how this disease impacts the production of small molecules using a mass spectrometry-based approach, which can provide insight into how relationships between the coral animal, algae, and bacteria may be impacted by this disease.”

She wishes to thank Assistant Professor Neha Garg “for her mentorship and the opportunities she has provided that have enabled me to develop my research skills.”
 

Quynh Nguyen

Quynh Nguyen is a third-year Ph.D. student looking into phase- and shape-controlled synthesis of nanocrystals for catalysis and energy-related applications. “What fascinates me is the ability to manipulate matter at the nanoscale to drive sustainable advances,” Nguyen says. “This field places me at the exciting intersection of chemistry, materials science, and nanotechnology, aiming to address current challenges in sustainability and renewable energy.”

Nguyen’s Ph.D. advisor is Younan Xia, professor, Brock Family Chair and Georgia Research Alliance Eminent Scholar in Nanomedicine. “Xia's guidance and expertise have been instrumental in shaping my research focus and methodology. Beyond the lab, he has consistently encouraged me to pursue opportunities that contribute to both my academic and professional development, for which I am immensely grateful.”

Eliza Gazda

Eliza Gazda, a fifth-year graduate scholar, is working in the field of multi-messenger particle astrophysics.

Gazda designed, tested, and integrated a telescope camera which was the payload on a scientific balloon launched in May. “The telescope launched is the first optical balloon of this type that operated at high altitudes over 30 kilometers,” Gazda says. “Our telescope observed radiative air showers from high energy cosmic rays and particles which travel across the Earth from extreme astrophysical objects like neutron stars and black holes. Once analyzed, this work will give us insight into high energy events that occur in space, and allow us to design and launch future similar telescopes.”

 Gazda’s mentor is Associate Professor Nepomuk Otte, “who guided me in the past through a summer internship at Georgia Tech and inspired me to come back to work on my Ph.D. here. Not only has he taught me lab skills, but he helps me with my career goals, and guides me in exploring our research field, networking, and learning about various disciplines within the field.”

Sydney Popsuj 

A fifth-year Ph.D. student, Sydney Popsuj is researching the gene Dkk3 and how it might regulate neurodevelopment and neurodegeneration in tunicates, close siblings to vertebrates. “This gene is implicated in Alzheimer's disease and dementia, but because it is hard to study in disease models, we don't have a strong grasp on the general functionality of the gene. I am using tunicates as a model system to study because they are biphasic, meaning they have both a larval and adult stage. This work is very exciting to me because it incorporates large scale evolutionary questions, while also having an impact on better understanding a gene that seems quite important to diseases and disorders.”

Popsuj thanks Georgia Tech faculty members Shuyi Nie, Joe LaChance, Patrick McGrath, Tim Cope, and Billie Swalla at the University of Washington “for pushing me to find new and exciting avenues into how to relate and generalize my work. These mentors have also encouraged me to expand outside my comfort zone in academics and to embrace new technologies and approaches that will hopefully further expand methods and protocols available to tunicate researchers.”

Jose Luis Ramirez-Colón

A third-year graduate scholar, Jose Luis Ramirez-Colón “has always been fascinated by the question of where we come from, and my time at Georgia Tech has been dedicated to using science as a tool to further explore this question.” His research focuses on exploring the organic inventory present in carbonaceous chondrites, meteorites that are like time capsules from the early days of the Solar System. 

“Many organic classes present in all life as we know it, such as amino acids, sugars, and nucleobases, have been detected in these meteorites; therefore, there’s this idea that these meteorites might've delivered these essential building blocks to early Earth to kick-start life as we know it,” Ramirez-Colón says. His mission at Georgia Tech is to develop methods to detect, extract, and characterize those building blocks. 

Ramirez-Colón wants to acknowledge “the remarkable contributions of my advisor and mentor, Christopher Carr, who has played a pivotal role in propelling my journey as an advancing Puerto Rican scientist. Carr not only granted me the freedom to pursue the questions that have always ignited my passion for science, but also equipped me with the essential tools and resources needed to conduct meaningful research.”

Sidney Scott-Sharoni

Sidney Scott-Sharoni is entering her fourth year of Ph.D. studies. An engineering psychology major, Scott-Sharoni focuses on “understanding how humans interact and conceptualize artificial intelligence devices,” she explains. 

“Specifically, I investigate creative methods to convey information to calibrate users’ trust, and understand their psychological well-being, most often in automated vehicles,” Scott-Sharoni says. “I love my area of research because it combines the study of people with the study of innovative technology. I feel like I am researching the people of the future!”

 Scott-Sharoni’s advisor, Professor Bruce Walker, “has significantly helped my personal and professional development as a researcher. I am very grateful for his continued mentorship throughout my graduate education.”

The College of Sciences congratulates six of its graduate scholars who have won Herbert P. Haley Fellowships for the 2023-24 school year.

The new Haley Fellows are:

• Jessica Deutsch, School of Chemistry and Biochemistry
• Quynh Nguyen, School of Chemistry and Biochemistry
• Eliza Gazda, School of Physics
• Sydney Popsuj, School of Biological Sciences
• Jose Luis Ramirez-Colón, School of Earth and Atmospheric Sciences
• Sidney Scott-Sharoni, School of Psychology

Haley scholars receive a one-time merit award of up to $4,000 thanks to the generosity of the late Marion Peacock Haley. Haley’s estate established the creation of merit-based graduate fellowships at Georgia Tech in honor of her late husband, Herbert P. Haley (ME 1933). It is an award which may be held in conjunction with other funding, assistantships, or fellowships, if applicable. 

Meet the Haley Fellows

Jessica Deutsch

Jessica Deutsch is a fifth-year Ph.D. student studying analytical chemistry. “One of the most intriguing aspects of analytical chemistry is that the field focuses on studying invisible things in order to make sense of the visible,” Deuthsch says. “I am researching a deadly coral disease that affects Florida and Caribbean reefs. I aim to provide insight into how this disease impacts the production of small molecules using a mass spectrometry-based approach, which can provide insight into how relationships between the coral animal, algae, and bacteria may be impacted by this disease.”

She wishes to thank Assistant Professor Neha Garg “for her mentorship and the opportunities she has provided that have enabled me to develop my research skills.”
 

Quynh Nguyen

Quynh Nguyen is a third-year Ph.D. student looking into phase- and shape-controlled synthesis of nanocrystals for catalysis and energy-related applications. “What fascinates me is the ability to manipulate matter at the nanoscale to drive sustainable advances,” Nguyen says. “This field places me at the exciting intersection of chemistry, materials science, and nanotechnology, aiming to address current challenges in sustainability and renewable energy.”

Nguyen’s Ph.D. advisor is Younan Xia, professor, Brock Family Chair and Georgia Research Alliance Eminent Scholar in Nanomedicine. “Xia's guidance and expertise have been instrumental in shaping my research focus and methodology. Beyond the lab, he has consistently encouraged me to pursue opportunities that contribute to both my academic and professional development, for which I am immensely grateful.”

Eliza Gazda

Eliza Gazda, a fifth-year graduate scholar, is working in the field of multi-messenger particle astrophysics.

Gazda designed, tested, and integrated a telescope camera which was the payload on a scientific balloon launched in May. “The telescope launched is the first optical balloon of this type that operated at high altitudes over 30 kilometers,” Gazda says. “Our telescope observed radiative air showers from high energy cosmic rays and particles which travel across the Earth from extreme astrophysical objects like neutron stars and black holes. Once analyzed, this work will give us insight into high energy events that occur in space, and allow us to design and launch future similar telescopes.”

 Gazda’s mentor is Associate Professor Nepomuk Otte, “who guided me in the past through a summer internship at Georgia Tech and inspired me to come back to work on my Ph.D. here. Not only has he taught me lab skills, but he helps me with my career goals, and guides me in exploring our research field, networking, and learning about various disciplines within the field.”

Sydney Popsuj 

A fifth-year Ph.D. student, Sydney Popsuj is researching the gene Dkk3 and how it might regulate neurodevelopment and neurodegeneration in tunicates, close siblings to vertebrates. “This gene is implicated in Alzheimer's disease and dementia, but because it is hard to study in disease models, we don't have a strong grasp on the general functionality of the gene. I am using tunicates as a model system to study because they are biphasic, meaning they have both a larval and adult stage. This work is very exciting to me because it incorporates large scale evolutionary questions, while also having an impact on better understanding a gene that seems quite important to diseases and disorders.”

Popsuj thanks Georgia Tech faculty members Shuyi Nie, Joe LaChance, Patrick McGrath, Tim Cope, and Billie Swalla at the University of Washington “for pushing me to find new and exciting avenues into how to relate and generalize my work. These mentors have also encouraged me to expand outside my comfort zone in academics and to embrace new technologies and approaches that will hopefully further expand methods and protocols available to tunicate researchers.”

Jose Luis Ramirez-Colón

A third-year graduate scholar, Jose Luis Ramirez-Colón “has always been fascinated by the question of where we come from, and my time at Georgia Tech has been dedicated to using science as a tool to further explore this question.” His research focuses on exploring the organic inventory present in carbonaceous chondrites, meteorites that are like time capsules from the early days of the Solar System. 

“Many organic classes present in all life as we know it, such as amino acids, sugars, and nucleobases, have been detected in these meteorites; therefore, there’s this idea that these meteorites might've delivered these essential building blocks to early Earth to kick-start life as we know it,” Ramirez-Colón says. His mission at Georgia Tech is to develop methods to detect, extract, and characterize those building blocks. 

Ramirez-Colón wants to acknowledge “the remarkable contributions of my advisor and mentor, Christopher Carr, who has played a pivotal role in propelling my journey as an advancing Puerto Rican scientist. Carr not only granted me the freedom to pursue the questions that have always ignited my passion for science, but also equipped me with the essential tools and resources needed to conduct meaningful research.”

Sidney Scott-Sharoni

Sidney Scott-Sharoni is entering her fourth year of Ph.D. studies. An engineering psychology major, Scott-Sharoni focuses on “understanding how humans interact and conceptualize artificial intelligence devices,” she explains. 

“Specifically, I investigate creative methods to convey information to calibrate users’ trust, and understand their psychological well-being, most often in automated vehicles,” Scott-Sharoni says. “I love my area of research because it combines the study of people with the study of innovative technology. I feel like I am researching the people of the future!”

 Scott-Sharoni’s advisor, Professor Bruce Walker, “has significantly helped my personal and professional development as a researcher. I am very grateful for his continued mentorship throughout my graduate education.”

Tara Holdampf is the new College of Sciences satellite counselor, and will provide consultation services and support for students from an office at the Molecular Science and Engineering Building (MoSE). 

“I'm excited to join the incredibly welcoming and talented group at the College of Sciences at Georgia Tech as a satellite counselor,” Holdampf says, “to continue the process of breaking down barriers between students and mental health services.”

Satellite counselor locations improve accessibility for students by providing counseling in places where students spend most of their time. Placing a counselor in an academic department helps to destigmatize mental health and may serve those who might hesitate to go to the Georgia Tech Counseling Center. A primary goal is to reach students who might not have otherwise sought out services. 

Holdampf will provide a wide variety of services such as individual counseling, group counseling, psycho-educational workshops, and walk-in hours for brief consultations (available to students, or faculty/staff who need to consult about a student). 

Holdampf issues a reminder that “as stress levels increase, and the fall semester continues, please know that GT CARE and GTCC are here to offer confidential support and services to students in need of mental healthcare.”

Currently enrolled interested students can reach out to GT CARE at (404) 894-3498 to schedule an initial assessment, and to be connected to health and wellness services. Current clients can continue to reach their GTCC counselor via email.

Holdampf will be offering consultation hours during which students, faculty, and staff can meet to learn more about mental health resources on campus, and/or to discuss a specific non-emergency student concern. These consults typically last 15 minutes. Those interested can email Holdampf at tara.holdampf@studentlife.gatech.edu to request a meeting. Holdampf will respond with a date/time and link/location for the consultation.

Find Tara's consultation hours and more resources here.

Students in need of mental health support after hours can call the GTCC main number at 404-894-2575, and follow the prompts to speak with an after-hours counselor.  Please visit the GTCC website for upcoming workshops, Let’s Talk sessions, and online offerings.

Holdampf, who has practiced in a higher education setting for seven years, has an M.S. in Clinical Mental Health Counseling and is a Licensed Professional Counselor in Georgia. Holdampf is also a Certified Clinical Trauma Professional and serves on the council of the Georgia College Counseling Association.

For his latest research on motor skills, visual learning, and their effects on human physiology, School of Biological Sciences associate professor Lewis Wheaton and his team went all the way back to the Paleolithic Era to study a very retro skill: stone toolmaking.

“One of the cool things about this particular study,” Wheaton says, “is this opportunity to look at a completely novel motor task, something most people have no idea how to do, and that’s making a stone tool.”

The new research, published today in Communications Biology, attempts to fill in the gaps when it comes to the science of how we learn complex motor skills — and what may be required to relearn them. 

Wheaton says there are studies researching the behavioral changes that are involved with learning complex skills. But research is still thin on how people adapt their visuomotor skills (how vision and movements combine) to carry out a complex task. Wheaton’s current study sought to quantify and evaluate the changes and relationship in action perception processes – how we understand actions, then select, organize, and interpret what needs to be done for a particular task. 

“The overall motivation was to determine if we could see any kind of emerging relationship between the perceptual system and the motor system, as somebody is really trying to learn to do this skill,” Wheaton says. Those are important processes to understand, he adds, not just for how people attain complex motor skills learning, but what would be needed for motor relearning, as in a rehabilitation setting.

Wheaton conducted the research with graduate students Kristel Yu Tiamco Bayani and Nikhilesh Natraj, plus three researchers from Emory University’s Department of Anthropology.

Tracking the eyes to learn about learning 

The test subjects in the study watched videos of paleolithic stone toolmaking for more than 90 hours of training. The subjects’ visual gaze patterns and motor performance were checked at three different training time points: the first time they watched the video, at 50 hours of training, and at approximately 90 hours. Everybody was able to make a stone tool (with varying degrees of success) at 90 hours, but some picked up the skills at 50 hours.

Wheaton says there was a lot of information to pay attention to in the videos. “There’s a lot of physics in (making stone tools). You’re hitting a rock which is made up of all different kinds of material. There could be a fissure or fault lines, and if you hit it the wrong way it could crumble. When you’re doing it at first, you don’t know that.”

As the video training went on, the participants started to pick up cues about how to strike the rock, along with other aspects of toolmaking. “At first you’re watching from curiosity, then you’re watching with intent.”

That was the exciting part for Wheaton and his team: Being able to see the different phases of learning during the training — which they actually could see by monitoring gaze tracking, or where the subjects’ eyes landed on the video screen as they watched (see photo.)

“Part of the study was to understand the variability where they are visually focused as they get better at the task,” he says.

That’s how Wheaton’s team found there are certain parts of the skills learning that connect better to gaze, but others that connect better to the physical act of making a stone tool. “As you’re going through time, your motor abilities are changing, and at some point that allows you to watch somebody else perform the same task differently, suggesting you’re able to follow the action better, and pull more information from the video in a much clearer way.”

The study not only found a connection between gaze and motor skills learning, but that the connection evolved as the learning went on. The next step in this research, Wheaton says, should include brain imaging “heat maps” to determine where learning takes place with this process. 

That could also help Wheaton’s team apply these lessons for rehabilitation purposes.

“That’s the link between that and some of the other work we’ve done in a rehab context,” he says. “If you’re watching somebody perform a task, if you’re undergoing rehab, there are different ways you’re watching the task. You’re not always watching it the same way. Maybe it depends on how good you are, or how you’re impaired, but all those variables play a role into what you’re visually pulling out” of the rehab training.

DOI: doi.org/10.1038/s42003-021-02768-w

Atlanta is often called the “city in a forest” because of its lush canopy of trees, uncommon for a major city. In the heart of that forest sits Georgia Tech’s 400-acre campus. And within campus lies a variety of wildlife that has made Georgia Tech its home.

“I don’t think most people are aware of wildlife on campus,” said Emily Weigel, senior academic professional in the School of Biological Sciences. “They might see a feral cat here or there, but they don’t really think about all the other animals that live on campus. Georgia Tech is the animals’ home base, and they probably don’t know anything other than they were born in this area. They don’t know they’re in the middle of a city.”

Included in the biodiversity surveys of the area are squirrels, possums, raccoons, rats, and birds. Several months ago a couple of coyotes were spotted, but they were just passing through campus. At least two foxes live in the glade, a densely forested area behind the president’s residence on the north side of campus.

Ben Seleb, a Ph.D. student in quantitative biosciences, is developing an open source camera for studying the foxes and other wildlife. He and his colleagues at Tech4Wildife, a course and campus organization devoted to the conservation of wildlife, have been monitoring the foxes.

“We had some suspicions that foxes were in the glade,” Seleb said. “It’s a very secluded area with dense vegetation, so it’s a great spot for campus wildlife to hide during the day and then come out at night.”

To confirm their suspicions, they set up cameras inside the glade and left them for a couple of weeks. When they reviewed the images, they had captured two foxes on camera at the same time.

“We know there could be more, but we’ve only seen two foxes at one time. They’re difficult to tell apart, but we’re working on identifying individuals,” he said. “There are a number of other animals on campus, and the glade is where many of them live. We have seen raccoons, possums, and a couple of feral cats that travel in and out of the glade.”

The glade connects to Tech’s new EcoCommons, a lush 8-acre woodland area near the center of campus, providing a pathway for wildlife to travel into campus at night, while still giving them the cover of vegetation. Georgia Tech generally offers a handful of classes related to wildlife or ecology, but the amount of wildlife on campus is creating new research opportunities.

“I’m happy to see programs giving students opportunities that they may not have been aware of,” Seleb said.

By Frida Carrera

As one of the nation’s leading research institutions, Georgia Tech has always emphasized the pursuit of progress and service in its research endeavors. With such a strong focus on research, it is only right that many students at Tech have seized their opportunities to make an impact on the real world and solve complex problems. Taking initiative, asking the right questions, and being passionate about making a positive impact are innate characteristics that make a researcher, and Georgia Tech has in no way come short of giving rise to many exemplary researchers. The following undergraduate student researchers are serving as catalysts for innovation and development in their respective fields and are representative of Georgia Tech’s mission in developing leadership and improving the human condition. 

Prahathishree (Premi) Mohanavelu is a 5^th-year Computer Science major with a Pre-Health concentration. She conducts research with Dr. Cassie Mitchell in Biomedical Engineering on informatics-based literature mapping to personalize therapy for Chronic Myeloid Leukemia. 

“I was really looking for a way to apply the concepts I was learning in my computer science classes to the field of healthcare, and I felt this position was the perfect fit for that.” 

One of her main reasons for conducting this research was her interest in medical innovation. Premi believes the future of medicine will rely on preventative care and says her research position has also helped her with oral presentation and communication skills. Premi also serves as president of the Undergraduate Research Ambassadors and utilizes her research role and experience to teach prospective research students the ins and outs of obtaining research knowledge.

Yiyang (Diana) Wang is a 4^th-year Computer Science major conducting research with Dr. Jennifer Kim on contact tracing visualization tool design and implementation. Her research is applicable to easily contracted illnesses including COVID-19. Yiyang believes her research will help people understand the importance of contact tracing and how data collection, for contact tracing purposes, could be beneficial. Yiyang’s goal is to become a software engineer and wants to focus on improving technology for the benefit of the user. Yiyang thanks the Undergraduate Research Opportunities Program (UROP) for obtaining her position as it was a major resource for her in finding and landing her current research position. 

Milan Riddick is currently a 5^th-year Biomedical Engineering major with a minor in Health, Medicine, and Society conducting research with Dr. Jennifer Singh in the area of History, Technology, and Society on the mistrust of the COVID-19 vaccine among black citizens of Georgia. Milan has been the primary lead in her own research and has combined her passions for medical sociology and research to do what she loves. From proposing, securing funding, recruiting, and interviewing, Milan had a vision from the start and hopes to understand and improve the trust disparity between black Georgia citizens and the COVID-19 vaccine. Milan hopes her current research will aid with the trust between people and medicine as well as securing her path to graduate school.

William York is a 4^th-year Biomedical Engineering major with a concentration in Pre-Health. He is currently conducting research with Dr. Edward Botchwey on using biomaterials to immunomodulate muscular defects for tissue regeneration. He believes his research is important because it will aid in the initiative in potentially replacing stem cells with exosomes in stem cell research while retaining the same regenerative effects and creating fewer risks. William wasn’t sure about research when he first arrived at Tech, but after learning the opportunities and resources UROP had for undergraduate students, he quickly became involved. William is now currently in the Research Option program and is also an Undergraduate Research Ambassador providing guidance to students also interested in research. 

Hannah Shin is a 3^rd-year Biology major with a concentration in Physiology and is conducting research with Dr. Colin Harrison on measuring the organization of biological knowledge around experimental design utilizing a card sorting task. Hannah’s research uses its results to identify the weak areas in biology programs and make the necessary revisions to instruct students more effectively. Hannah believes her research will also aid her in future endeavors. 

 “My career goal is medical school and I believe my research will advance both my academic and career goals because it exposes me to real-world applications of data analysis and allows me to dive into the differences in knowledge organization among people of different backgrounds.” 

 Hannah is also a participant in the Research Option program and is the executive vice president of the Undergraduate Research Ambassadors. She uses her research and personal experience to help students gain confidence in pursuing research they are passionate about. 

Read more about Undergraduate Research opportunities by going to http://urop.gatech.edu. 

Cancer chemotherapy has undergone a paradigm shift in recent years with traditional treatments like broad-spectrum cytotoxic agents being complemented or replaced by drugs that target specific genes believed to drive the onset and progression of the disease.

This more personalized approach to chemotherapy became possible when genomic profiling of individual patient tumors led researchers to identify specific "cancer driver genes" that, when mutated or abnormally expressed, led to the onset and development of cancer.

Different types of cancer — like lung cancer versus breast cancer — and, to some extent, different patients diagnosed with the same cancer type — show variations in the cancer driver genes believed to be responsible for disease onset and progression. “For example, the therapeutic drug Herceptin is commonly used to treat breast cancer patients when its target gene, HER-2, is found to be over-expressed,” says John F. McDonald, professor in the School of Biological Sciences.

McDonald explains that, currently, the identification of potential targets for gene therapy relies almost exclusively on genomic analyses of tumors that identify cancer driver genes that are significantly over-expressed.

But in their latest study, McDonald and Bioinformatics Ph.D. student Zainab Arshad have found that another important class of genetic changes may be happening in places where scientists don’t normally look: the network of gene-gene interactions associated with cancer onset and progression.

“Genes and the proteins they encode do not operate in isolation from one another,” McDonald says. “Rather, they communicate with one another in a highly integrated network of interactions.”

“What I think is most remarkable about our findings is that the vast majority of changes — more than 90% — in the network of interactions accompanying cancer are not associated with genes displaying changes in their expression,” adds Arshad, co-author of the paper. “What this means is that genes playing a central role in bringing about changes in network structure associated with cancer — the ‘hub genes’ — may be important new targets for gene therapy that can go undetected by gene expression analyses.”

Their research paper “Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression” is published in the journal iScience.

Mutations, expression — and changes in network structure

In the study, Arshad and McDonald worked with samples of brain, thyroid, breast, lung adenocarcinoma, lung squamous cell carcinoma, skin, kidney, ovarian, and acute myeloid leukemia cancers — and they noticed differences in cell network structure for each of these cancers as they progressed from early to later stages.

When early-stage cancers develop, and stayed confined to their body tissue of origin, they noted a reduction in network complexity relative to normal pre-cursor cells. Normal, healthy cells are highly differentiated, but as they transition to cancer, “[T]hey go through a process of de-differentiation to a more primitive or stem cell-like state. It’s known from developmental biology that as cells transition from early embryonic stem cells to highly specialized fully differentiated cells, network complexity increases. What we see in the transition from normal to early-stage cancers is a reversal of this process,” McDonald explains.

McDonald says as the cancers progress to advanced stages, when they can spread or metastasize to other parts of the body, “[W]e observe re-establishment of high levels of network complexity, but the genes comprising the complex networks associated with advanced cancers are quite different from those comprising the complex networks associated with the precursor normal tissues.”

“As cancers evolve in function, they are typically associated with changes in DNA structure, and/or with changes in the RNA expression of cancer driver genes. Our results indicate that there’s an important third class of changes going on — changes in gene interactions — and many of these changes are not detectable if all you’re looking for are changes in gene expression.”

DOI: https://doi.org/10.1016/j.isci.2021.103522

Acknowledgments: This research was supported by the Mark Light Integrated Cancer Research Center Student Fellowship , the Deborah Nash Endowment Fund , and the Ovarian Cancer Institute (Atlanta), where John F. McDonald serves as chief research officer. The results shown here are based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/.

About Georgia Institute of Technology

The Georgia Institute of Technology, or Georgia Tech, is a top 10 public research university developing leaders who advance technology and improve the human condition. The Institute offers business, computing, design, engineering, liberal arts, and sciences degrees. Its nearly 40,000 students representing 50 states and 149 countries, study at the main campus in Atlanta, at campuses in France and China, and through distance and online learning. As a leading technological university, Georgia Tech is an engine of economic development for Georgia, the Southeast, and the nation, conducting more than $1 billion in research annually for government, industry, and society.

Black soldier fly larvae devour food waste and other organic matter and are made of 60% protein, making them an attractive sustainable food source in agriculture. But increasingly, black soldier larvae are dying before they reach livestock facilities as animal feed. 

Georgia Tech researchers, recognizing the culprit is the collective heat generated when the maggots eat in crowded conditions, have found that delivering the right amount of airflow could help solve the overheating issue. Their findings were published this month in Frontiers in Physics as part of a special issue on the “Physics of Social Interactions.”

“Black soldier fly larvae are widely used in an emerging food-recycling industry. The idea is to feed the larvae with food waste and then turn them into chicken feed,” explained first author Hungtang Ko, a Ph.D. student in the George W. Woodruff School of Mechanical Engineering.  “These larvae make a great candidate for this process because they eat just about everything.”

Each year humans waste more than one billion tons of food, or a third of all food production, and many countries are running out of options for disposing of this waste.

The larvae thrive in and around compost piles, where their larvae help break down organic material, from rotten produce to animal remains and manure. Black soldier fly larvae commonly grow to about 1,000 times their size, noted David Hu, professor in the School of Mechanical Engineering.

“It’s like going from the size of a person to the size of a big truck,” he said of the larvae’s growth from eggs to adults.

Hu has appeared on Science Friday graphically showing the voracious appetite of black soldier fly larvae, which can eat twice their body mass in food per day. But when these maggots feed while tightly packed in container bins, they generate metabolic heat that collectively can turn lethal for them.

Air Flow Matters

Ko and Hu collaborated with Daniel Goldman, Dunn Family Professor in the School of Physics, to set up the experiments. Goldman uses fluidized beds —widely used in industrial applications like oil refining ― to control properties of granular media in animal and robot locomotion studies. Fluidized beds operate by forcing a vertical flow of fluid through a collection of particulate matter; above a certain flow rate, the grains transition from a solid pile to a fluid-like arrangement, where they collide and jostle.  

The researchers placed the larvae in a container subjected to regular air flow at a consistent temperature. They then attached a leaf blower to supply air flow into the chamber, manually ramping up and down the air speed in five-minute trials.

Because of the larvae’s constant activity, the collectives’ behavior under air fluidization differs from what is observed in traditional fluidized beds: larvae were un-jammable when air flow became low. Instead, they behave like a fluid that adapted and adjusted to external forces.

“An interesting aspect of this work is that it probes a regime of ‘active matter,’ which has received less attention from physicists: Instead of 3D swarms composed of widely separated, non-colliding flying birds and insects, our `swarm’ exists in another regime, where animals are packed tightly together,” Goldman said.

In a second experiment, the team used x-ray imaging and constant air speed to see how fast larvae eat. Specifically, Ko measured the average velocity and pressure of the larvae, as well as how much food they ate under various airflow speeds.

“As you continue to increase the flow, you’ll reach a point where all the larvae are flying [through the air]. The airflow is too fast, and they won’t eat well,” he said.   

Optimal air velocity will ensure the larvae are cooled off properly and can still feed effectively. “Probing optimal flow velocity will be a good next step. Also, from an engineering perspective, we need to consider other ways that we can cool the larvae down, including using heat transfer,” he added. 

The results indicated that as larvae are agitated by rapid flows, the insects are more likely to be suspended in mid-air without contacting the food, suggesting that a moderate flow rate would be optimal for feeding dense groups of larvae.

The researchers also hope this work will enable black soldier fly larvae to be more readily available as recyclers of food waste, which totals 1.3 billion tons per year, according to the Food and Agriculture Organization of the United Nations. But just as important is the potential of these protein-rich insects to reduce the carbon effects of feeding animals. Global food production contributes more than 17 billion metric tons of human-made greenhouse gas emissions every year, according to a study published in September in Nature Food. Animal-based foods produce more than twice the emissions of plant-based food, the study found. 

“There's no sustainable protein source for the animals that we eat,” noted Ko. “The black soldier fly larvae could play a role in reducing the environmental impact of feeding these animals.”

CITATION: H. Ko, et. all, “Air-Fluidized Aggregates of Black Soldier Fly Larvae,” (Frontiers in Physics, 2021) https://doi.org/10.3389/fphy.2021.734447

As of this week, the omicron variant makes up the majority of new coronavirus cases in the U.S. Omicron is more contagious than previous variants and has caused a spike in cases across the nation, including locally.

The same prevention measures that have been put in place previously can still help slow the spread of this variant — vaccination, wearing a face covering, physical distancing, and regular surveillance testing. A well-fitting mask with good filtration is a strong defense for when you are out in public, even if you are fully vaccinated.

As the campus community looks toward winter break, Georgia Tech encourages all students, faculty, and staff to get fully vaccinated, including a booster shot. Campus vaccination clinics will resume in January; to find a vaccination site before that, visit vaccines.gov. Vaccines help reduce the risk of severe illness and hospitalization.

Anyone with Covid-19 symptoms — even mild ones — should get tested and wait for a negative result before interacting with others. Testing on campus is closed through winter break and will resume Tuesday, Jan. 4, 2022. Until then, you can find an alternate testing site.

We recommend all students, faculty, and staff plan to get tested off-campus before returning for the spring semester, and we recommend each person test again on campus upon their return. Campus testing sites will reopen at full capacity on Jan. 4th to accommodate those returning to campus.