Monica’s research will focus on a systems biology approach towards the developing of a malaria vaccine. Using gene expression profiling of the human immune response to malaria vaccination, Monica hopes to investigate the safety and efficacy of vaccines, along with the most effective strategies of vaccine implementation.
Congratulations to the following faculty and staff members who were honored at the 2014 Faculty and Staff Honors Luncheon on April 11.
Fish living on coral reefs where carbon dioxide seeps from the ocean floor were less able to detect predator odor than fish from normal coral reefs, according to a new study.
The study confirms laboratory experiments showing that the behavior of reef fishes can be seriously affected by increased carbon dioxide concentrations in the ocean. The new study is the first to analyze the sensory impairment of fish from CO2 seeps, where pH is similar to what climate models forecast for surface waters by the turn of the century.
From time to time, living cells will accidently make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous genes into a source of genetic novelty, adaptation and diversity. A new study shows one way that some duplicate genes could have long-ago escaped elimination from the genome, leading to the genetic innovation seen in modern life.
Jeff Skolnick awarded for fostering excellence in scientific research
If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient’s cancer treatment on commonly disrupted genes and pathways.
Exploiting the use of DNA single- and double-strand breaking forms of the I-SceI endonuclease to stimulate homologous recombination and gene targeting in budding yeast and in human cells, the research of Samantha S. Katz in Francesca Storici’ lab provides new mechanistic insights into the process of nick-induced DNA recombination and on the function of nicking enzymes in genetic engineering.
Taking a DNA molecule into the vicinity of a homologous target gene by a DNA aptamer provides a many-fold enhancement of gene correction frequency at that genetic locus. Aptamer-guided gene targeting, or AGT, is a novel approach for genetic engineering developed by Patrick Ruff in Francesca Storici’s group.
Competition may have a high cost for at least one species of tropical seaweed. Researchers examining the chemical warfare taking place on Fijian coral reefs have found that one species of seaweed increases its production of noxious anti-coral compounds when placed into contact with reef-building corals, but at the same time becomes more attractive to herbivorous fish.