I work on nanoparticles called exosomes that are secreted by cells and are used to transfer functional biomolecules between cells. My work is focused on understanding the impact of the cargo on downstream recipient cells under normal states and TLR stimulation states. TLR signaling is a critical innate immune response pathway that helps in rapid pathogen response. I am working on understanding the impact of both viral (TLR3) and bacterial (TLR4) stimulation on the exosome content as well as recipient cell phenotype using transcriptomics and proteomics.
I am co-advised by J. Brandon Dixon in Mechanical Engineering and with this collaboration, I have been able to characterize the uptake and transport of exosomes in the lymphatic system in vivo using the near infrared imgaing platform developed in his lab. I am currently working on elucidating the impact of differentially stimulated exosomes on the transcriptional response at the lymph node