"The Role of Pet Dogs in Veterinary Clinical Trials in Preparation for Human Clinical Trials in Neuroscience"
Simon R Platt BVM&S MRCVS
Dipl. ACVIM (Neurology), Dipl. ECVN
Professor Neurology & Neurosurgery
Department of Small Animal Medicine & Surgery
College of Veterinary Medicine
University of Georgia
Much of the progress made in neuroscience has relied on rodent models. Although these models have helped tremendously advance the understanding of neurologic disease pathogenesis, treatment breakthroughs have been hampered by the fact that these models do not truly translate to what is seen in humans. The bases for this 'lost in translation' has been suggested to be due to different brain white and grey matter composition, different brain structure and size, a lack on a natural immune systems in many rodent models as well as a lack of heterogeneity in these models which are often induced rather than naturally occurring. Dogs have a similar genetic make up to humans, a similarly structured nervous system and a exhibit the same type of naturally occurring diseases - does the pet dog then represent the perfect model for treatment trials which will finally translate into successful therapies in humans?